Homopterocarpin

Names

[ CAS No. ]:
606-91-7

[ Name ]:
Homopterocarpin

[Synonym ]:
6H-Benzofuro[3,2-c][1]benzopyran, 6a,11a-dihydro-3,9-dimethoxy-, (6aR,11aR)-rel-
6H-Benzofuro[3,2-c][1]benzopyran, 6a,11a-dihydro-3,9-dimethoxy-, (6aR,11aR)-
6H-Benzofuro[3,2-c][1]benzopyran, 6a,11a-dihydro-3,9-dimethoxy-, (6aR-cis)-
(6aR,11aR)-3,9-Dimethoxy-6a,11a-dihydro-6H-[1]benzofuro[3,2-c]chromene
6H-Benzofuro(3,2-c)(1)benzopyran, 6a,11a-dihydro-3,9-dimethoxy-, (6aR,11aR)-rel-

Biological Activity

[Description]:

Homopterocarpin is an isoflavonoid that can be isolated from Pterocarpus erinaceus. Homopterocarpin has hepatoprotective and antioxidant properties. Homopterocarpin is a competitive reversible inhibitor of human monoamine oxidase-B with an IC50 and a Ki of 0.72 and 0.21 μM for hMAO-B, respectively. Homopterocarpin can be used for the research of liver injury and oxidative stress[1][2].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase

Research Areas >> Inflammation/Immunology

[References]

[1]. Akinmoladun AC, et al. Effect of homopterocarpin, an isoflavonoid from Pterocarpus erinaceus, on indices of liver injury and oxidative stress in acetaminophen-provoked hepatotoxicity. J Basic Clin Physiol Pharmacol. 2015 Nov;26(6):555-62.

[2]. Oh JM, et al. Medicarpin and Homopterocarpin Isolated from Canavalia lineata as Potent and Competitive Reversible Inhibitors of Human Monoamine Oxidase-B. Molecules. 2022 Dec 28;28(1):258.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
395.0±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₆O₄

[ Molecular Weight ]:
284.306

[ Flash Point ]:
140.4±34.7 °C

[ Exact Mass ]:
284.104858

[ PSA ]:
36.92000

[ LogP ]:
3.14

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.589

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2932999099

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%