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A 77-01

Names

[ CAS No. ]:
607737-87-1

[ Name ]:
A 77-01

[Synonym ]:
4-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-quinolone
A 77-01

Biological Activity

[Description]:

A 77-01 is a potent inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM. IC50 Value: 25 nM [1]Target: ALK5A-77-01 is a close analogue of A-83-01(Axon 1421) and has a very similar biological profile of A-83-01. A-83-01 is found to decompose to A-77-01 under certain circumstances and A-77-01 is likely an active component or metabolite of its prodrug A-83-01.

[Related Catalog]:

Signaling Pathways >> TGF-beta/Smad >> TGF-β Receptor
Research Areas >> Cancer

[References]

[1]. Tojo M, et al. The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. Cancer Sci. 2005 Nov;96(11):791-800.


[Related Small Molecules]

SB431542 | Galunisertib (LY2157299) | A 83-01 | LY2109761 | LDN193189 | RepSox | SB525334 | Vactosertib (TEW-7197) | DMH-1 | GW788388 | LY364947 | SB505124 | LY3200882 | H-Leu-Ser-Lys-Leu-NH2 trifluoroacetate salt | ITD-1

Chemical & Physical Properties

[ Density]:
1.254g/cm3

[ Boiling Point ]:
481.63ºC at 760 mmHg

[ Molecular Formula ]:
C18H14N4

[ Molecular Weight ]:
286.33100

[ Flash Point ]:
256.391ºC

[ Exact Mass ]:
286.12200

[ PSA ]:
54.46000

[ LogP ]:
3.99530

[ Index of Refraction ]:
1.685

[ Storage condition ]:
2-8℃

Related Compounds