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(Thr4,Gly7)-Oxytocin

Names

[ CAS No. ]:
60786-59-6

[ Name ]:
(Thr4,Gly7)-Oxytocin

[Synonym ]:
3,3-DiallylthiacarbocyanineBromide
CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2
[THR4,GLY7] OT
H-CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2,(DISULFIDE BOND)
Cys-Tyr-Ile-Thr-Asn-Cys-Gly-Leu-Gly-NH2 (Disulfide bridge Cys1-Cys6)
TGOT
H-CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2
thr(4)-gly(7)-oxytoci
[THR4,GLY7]-OXYTOCIN

Biological Activity

[Description]:

(Thr4,Gly7)-Oxytocin, an Oxytocin analogue, is a specific OT receptor agonist. (Thr4,Gly7)-Oxytocin also excites subicular neurons via activation of TRPV1 channels, and depression of K+ channels. [1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Oxytocin Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[Target]

OT receptors, K+ channels[1].


[In Vitro]

(Thr4,Gly7)-Oxytocin (1 μM, 1 min) evokes an inward current of 5.9 pA in paraventricular thalamus (PVT) neurons[1]. (Thr4,Gly7)-Oxytocin (1 μM, 1 min) increases spontaneous excitatory postsynaptic currents (sEPSCs) frequency in PVT neurons[1]. (Thr4,Gly7)-Oxytocin (0.3 μM, 5 min) induces depolarization in both bursting cells and regular firing cells[2]. (Thr4,Gly7)-Oxytocin (0.3 μM, 5 min) depolarizes subicular neurons by activating TRPV1 channels[2].

[In Vivo]

(Thr4,Gly7)-Oxytocin (1 μM, direct intra-PVT infusion for 1 min) evokes depolarization on TGOT-responsive neurons in mice[1]. (Thr4,Gly7)-Oxytocin (100 ng, intracerebroventrical injection) increases nitric oxide production in the paraventricular nucleus of the hypothalamus of male rats[3]. Animal Model: Swiss Webster mice [1] Dosage: 1 μM Administration: Intratracheal administration for 24 h Result: Excited 34.3% of aPVT neurons, 57.6% of mPVT neurons, and 60.0% of pPVT neurons. Increased the firing rate of TGOT-responsive PVT neurons in all subregions.

[References]

[1]. Lily R Barrett, et al. Oxytocin activation of paraventricular thalamic neurons promotes feeding motivation to attenuate stress-induced hypophagia. Neuropsychopharmacology. 2021 Apr;46(5):1045-1056.

[2]. Binqi Hu, et al. Activation of Oxytocin Receptors Excites Subicular Neurons by Multiple Signaling and Ionic Mechanisms. Cereb Cortex. 2021 Mar 31;31(5):2402-2415.

[3]. M R Melis, et al. Oxytocin increases nitric oxide production in the paraventricular nucleus of the hypothalamus of male rats: correlation with penile erection and yawning. Regul Pept. 1997 Mar 26;69(2):105-11.

Chemical & Physical Properties

[ Density]:
1.332g/cm3

[ Molecular Formula ]:
C39H61N11O12S2

[ Molecular Weight ]:
940.09800

[ Exact Mass ]:
939.39400

[ PSA ]:
436.06000

[ LogP ]:
0.54950

[ Index of Refraction ]:
1.587

Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
20

[ Safety Phrases ]:
36/37/39-45

Related Compounds