Norbraylin

Names

[ Name ]:
Norbraylin

[Synonym ]:
6-Hydroxy-8,8-dimethyl-2H,8H-pyrano[2,3-f]chromen-2-one
2H,8H-Benzo[1,2-b:3,4-b']dipyran-2-one, 6-hydroxy-8,8-dimethyl-

Biological Activity

[Description]:

Norbraylin, a natural prenylated coumarin, is a PDE4D2 inhibitor with an IC50 value of 7.15 μM[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)

Research Areas >> Inflammation/Immunology

[Target]

PDE4D2:7.15 μM (IC50)

[References]

[1]. Lin Chen, et al. (P)/(M)-corinepalensin A, a pair of axially chiral prenylated bicoumarin enantiomers with a rare C-5C-5' linkage from the twigs of Coriaria nepalensis. Phytochemistry. 2018 May;149:140-145.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
471.1±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₂O₄

[ Molecular Weight ]:
244.243

[ Flash Point ]:
185.2±22.2 °C

[ Exact Mass ]:
244.073563

[ PSA ]:
59.67000

[ LogP ]:
2.72

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.612

Safety Information

[ HS Code ]:
2932999099

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%