Imidazolo-oxindole PKR inhibitor C16

Names

[ Name ]:
Imidazolo-oxindole PKR inhibitor C16

[Synonym ]:
(8Z)-8-(1H-imidazol-4-ylmethylidene)-6,8-dihydro-7H-[1,3]thiazolo[5,4-e]indol-7-one
(Z)-8-((1H-Imidazol-4-yl)methylene)-6H-thiazolo[5,4-e]indol-7(8H)-one
8-(1H-Imidazol-4-ylmethylene)-6,8-dihydro-thiazolo[5,4-e]indol-7-one
(8Z)-8-(1H-Imidazol-5-ylmethylene)-6,8-dihydro-7H-[1,3]thiazolo[5,4-e]indol-7-one
C16 (PKR inhibitor)
7H-Thiazolo[5,4-e]indol-7-one, 6,8-dihydro-8-(1H-imidazol-5-ylmethylene)-, (8Z)-

Biological Activity

[Description]:

PKR-IN-C16 is a specific protein kinase (PKR) inhibitor. PKR-IN-C16 is able to inhibit the autophosphorylation of PKR and unlock the translation blockade induced by PKR in primary neuronal cultures[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Tronel C, et al. The specific PKR inhibitor C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component. Neurochem Int. 2014 Jan;64:73-83.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
674.6±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₃H₈N₄OS

[ Molecular Weight ]:
268.294

[ Flash Point ]:
361.8±31.5 °C

[ Exact Mass ]:
268.041870

[ PSA ]:
98.91000

[ LogP ]:
0.80

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.851

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport