Meticillin

Names

[ CAS No. ]:
61-32-5

[ Name ]:
Meticillin

[Synonym ]:
Meticillin
meticillin
6β-(2,6-dimethoxy-benzoylamino)-penicillanic acid
METICILLIN
6-(2,6-dimethoxybenzamido)penicillinic acid
(2S,5R,6R)-6-[(2,6-dimethoxybenzoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Methicillin
methycillin

Biological Activity

[Description]:

Methicillin is a narrow-spectrum β-lactam antibiotic, acts by inhibiting penicillin-binding proteins (PBPs). Methicillin is active against Staphylococcus aureus and Staphylococcus epidermidis that are resistant to other penicillins.Methicillin can be used for the research of skin infections, osteomyelitis, and endocarditis[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Methicillin (20 μg/mL, 24 h) results in a rapid decrease in CFU of S. aureus[2].

[In Vivo]

Methicillin (Intramuscular administration, 40 mg/kg every 6 h, 5 days), in S. aureus.-infected rabbits[2].

[References]

[1]. Sharon S. Castle. Methicillin. xPharm: The Comprehensive Pharmacology Reference 2007, Pages 1-4.

[2]. Jaime Carrizosa, et al. Treatment of Experimental Staphylococcus aureus Endocarditis: Comparison of Cephalothin, Cefazolin, and Methicillin. Antimicrob Agents Chemother. 1978 Jan; 13(1): 74–77.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₂₀N₂O₆S

[ Molecular Weight ]:
380.41600

[ Exact Mass ]:
380.10400

[ PSA ]:
130.47000

[ LogP ]:
1.27790

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
XH8930000

Precursor & DownStream

Precursor

DownStream

Articles

Antimicrobial properties of membrane-active dodecapeptides derived from MSI-78.

Biochim. Biophys. Acta 1848(5) , 1139-46, (2015)

Antimicrobial peptides (AMPs) are a class of broad-spectrum antibiotics known by their ability to disrupt bacterial membranes and their low tendency to induce bacterial resistance, arising as excellen...

Bacteriophage as effective decolonising agent for elimination of MRSA from anterior nares of BALB/c mice.

BMC Microbiol. 14 , 212, (2014)

Nasal carriers not only pose serious threat to themselves but also to the community by playing an active role in the dissemination of serious and life threatening S. aureus especially MRSA strains. Th...

Preparation and in vitro-in vivo evaluation of ofloxacin loaded ophthalmic nano structured lipid carriers modified with chitosan oligosaccharide lactate for the treatment of bacterial keratitis.

Eur. J. Pharm. Sci. 63 , 204-15, (2014)

The objective of this study was to explore the potential of the nanostructured lipid carriers (NLCs) modified with chitosan oligosaccharide lactate (COL) for topical ocular application. Ofloxacin (OFX...