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Cyclic-di-GMP

Names

[ CAS No. ]:
61093-23-0

[ Name ]:
Cyclic-di-GMP

[Synonym ]:
Cyclic diguanylate
cyclic di-GMP
3',5'-Cyclic diguanylic acid
Cyclic-di-GMP

Biological Activity

[Description]:

Cyclic-di-GMP is a STING agonist and a ubiquitous second messenger that regulates biofilm formation, motility, and virulence in diverse bacterial species.

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> STING
Research Areas >> Cancer

[Target]

STING[1]


[References]

[1]. Nakamura T, et al. Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma. J Control Release. 2015 Oct 28;216:149-57.

[2]. Burdette DL, et al. STING is a direct innate immune sensor of cyclic di-GMP. Nature. 2011 Sep 25;478(7370):515-8.


[Related Small Molecules]

CCCP | ADU-S100 ammonium salt | DMXAA (Vadimezan) | G10, STING signaling activator | C 176 | cGAMP | STING agonist-1(compound 3)trihydrochloride

Chemical & Physical Properties

[ Molecular Formula ]:
C20H24N10O14P2

[ Molecular Weight ]:
690.41100

[ Exact Mass ]:
690.09500

[ PSA ]:
371.22000

[ Storage condition ]:
2-8℃

Related Compounds