6,8-DIHYDROXYPYRENE-1,3-DISULFONIC ACID DISODIUM SALT

Names

[ Name ]:
6,8-DIHYDROXYPYRENE-1,3-DISULFONIC ACID DISODIUM SALT

[Synonym ]:
DHPDS
Disodium 6,8-dihydroxy-1,3-pyrenedisulfonate
6,8-Dihydroxy-1,3-pyrenedisulfonic acid disodium salt

Biological Activity

[Description]:

DHPDS disodium salt is a pH-sensitive fluorescent dye. DHPDS disodium salt is used to measure intracellular pH (pHi) from the surface fluorescence of the isolated perfused rat liver[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Felberbauer FX, et al. Fiber-optic measurement of intracellular pH in intact rat liver using pH-sensitive dyes. Pflugers Arch. 1991;419(2):215-217.

Chemical & Physical Properties

[ Melting Point ]:
≥250ºC(lit.)

[ Molecular Formula ]:
C₁₆H₈Na₂O₈S₂

[ Molecular Weight ]:
438.34

[ Exact Mass ]:
437.94600

[ PSA ]:
171.62000

[ LogP ]:
3.96500

[ Water Solubility ]:
DMF: soluble

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

O.S. Wolfbeis et al.

Fresenius J. Anal. Chem. 314 , 119, (1983)

Fiber-optic measurement of intracellular pH in intact rat liver using pH-sensitive dyes.

Pflugers Arch. 419 , 215, (1991)

The pH-sensitive fluorescent dye 1,3-dihydroxy-pyrene-6,8-disulfonic acid (DHPDS) was used to measure intracellular pH (pHi) from the surface fluorescence of the isolated perfused rat liver. Monochrom...

[Measurement of intracellular pH].

Nihon Rinsho. 50 , 2048-2053, (1992)

Since various cellular processes depend on changes in pH, the regulation of intracellular pH (pHi) is important both for the individual cell and for the organism. The mechanisms of the regulation of p...