acetoaminophenol

Names

[ CAS No. ]:
614-80-2

[ Name ]:
acetoaminophenol

[Synonym ]:
2-acetamidophenol
o-(Acetylamino)phenol
EINECS 210-396-9
2-hydroxyacetanilide
2-Acetamino
2-acetamido-pheno
N-(2-Hydroxyphenyl)acetamide
o-Acetamidophenol
Phenol, 2-acetamido-
2-acetaminophenol
Acetamide, N-(2-hydroxyphenyl)-
MFCD00002181
N-Acetyl-2-aminophenol
O AcetaMinophen
2-Acetamido phenol
2'-Hydroxyacetanilide
Acet-o-aminofenol
N-Acetyl-o-aminophenol
2-acetylamino-1-hydroxybenzene
acetoaminophenol
o-Acetaminophenol

Biological Activity

[Description]:

Paracetamol (4-acetamidophenol). 2-Acetamidophenol is a promising analgesic and an anti-arthritic agent[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Andrusenko I, et al. The Crystal Structure of Orthocetamol Solved by 3D Electron Diffraction. Angew Chem Int Ed Engl. 2019 Aug 5;58(32):10919-10922.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
343.1±25.0 °C at 760 mmHg

[ Melting Point ]:
205-210 °C(lit.)

[ Molecular Formula ]:
C₈H₉NO₂

[ Molecular Weight ]:
151.163

[ Flash Point ]:
161.3±23.2 °C

[ Exact Mass ]:
151.063324

[ PSA ]:
49.33000

[ LogP ]:
0.72

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.619

[ Stability ]:
Stable. Incompatible with strong oxidizing agents, chloroformates, acids, acid chlorides, acid anhydrides.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AE4025000

CHEMICAL NAME :: Acetanilide, 2'-hydroxy-

CAS REGISTRY NUMBER :: 614-80-2

BEILSTEIN REFERENCE NO. :: 0607592

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C8-H9-N-O2

MOLECULAR WEIGHT :: 151.18

WISWESSER LINE NOTATION :: QR BMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 1 mmol/L

REFERENCE :: MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 3,51,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7933 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 198 (estimated) No. of Female Employees: 151 (estimated)

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
2811

[ WGK Germany ]:
3

[ RTECS ]:
AE4025000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
29242995

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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