MK-212

Names

[ Name ]:
MK-212

[Synonym ]:
6-chloro-2-(piperazinyl)pyrazine hydrochloride
1-(6-Chloro-2-pyrazinyl)piperazine hydrochloride
1-(6-chloropyrazin-2-yl)piperazine hydrochloride
Sodium chloride
6-chloro-2-(1-piperazinyl)-pyrazine hydrochloride
MK 212 hydrochloride
4-(2chloro-6-pyrazinyl)piperazine hydrochloride
MK-212

Biological Activity

[Description]:

MK-212 (CPP) monohydrochloride is a centrally acting 5-HT1C/5-HT2 agonist. MK-212 monohydrochloride can stimulate phosphoinositide hydrolysis in cerebral cortex[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[Target]

5-HT1C Receptor

5-HT2 Receptor

[References]

[1]. Lee HS, et, al. Effect of the serotonin agonist, MK-212, on body temperature in schizophrenia. Biol Psychiatry. 1992 Mar 1;31(5):460-70.

[2]. Conn PJ, et, al. Relative efficacies of piperazines at the phosphoinositide hydrolysis-linked serotonergic (5-HT-2 and 5-HT-1c) receptors. J Pharmacol Exp Ther. 1987 Aug;242(2):552-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C₈H₁₂Cl₂N₄

[ Molecular Weight ]:
235.11400

[ Exact Mass ]:
234.04400

[ PSA ]:
41.05000

[ LogP ]:
1.73540

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ Hazard Codes ]:
T+

[ Risk Phrases ]:
H301

[ RIDADR ]:
UN 2811 6.1 / PGIII

[ HS Code ]:
2933990090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Serotonin activates catecholamine neurons in the solitary tract nucleus by increasing spontaneous glutamate inputs.

J. Neurosci. 32(46) , 16530-8, (2012)

Serotonin (5-HT) is a critical neurotransmitter in the control of autonomic functions. 5-HT(3) receptors participate in vagal afferent feedback to decrease food intake and regulate cardiovascular refl...

Characterizing the effects of 5-HT(2C) receptor ligands on motor activity and feeding behaviour in 5-HT(2C) receptor knockout mice.

Neuropharmacology 57(3) , 259-67, (2009)

5-HT(2C) receptor agonists have considerable therapeutic potential, however there is little in vivo data to compare the potency and selectivity of 5-HT(2C) receptor agonists. Since 5-HT(2C) receptor a...

Different serotonin receptor agonists have distinct effects on sound-evoked responses in inferior colliculus.

J. Neurophysiol. 96(5) , 2177-88, (2006)

The neuromodulator serotonin has a complex set of effects on the auditory responses of neurons within the inferior colliculus (IC), a midbrain auditory nucleus that integrates a wide range of inputs f...