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OMDM-5

Names

[ CAS No. ]:
616884-66-3

[ Name ]:
OMDM-5

Biological Activity

[Description]:

OMDM-5 is a selective inhibitor of anandamide cellular uptake (ACU), with a Ki of 4.8 μM. OMDM-5 is also a potent vanilloid receptor type 1 (VR1, TRPV1) agonist, with an EC50 of 75 nM, and shows weakly active as cannabinoid receptor type 1 (CB1) ligand (Ki=4.9 μM)[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel
Research Areas >> Neurological Disease

[Target]

Ki: 4.8 μM (anandamide cellular uptake), 4.9 μM (CB1), EC50: 75 nM (VR1)[1]


[References]

[1]. Ortar G, et al. Novel selective and metabolically stable inhibitors of anandamide cellular uptake. Biochem Pharmacol. 2003 May 1;65(9):1473-81.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H44N2O3

[ Molecular Weight ]:
432.64

Related Compounds