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Vorapaxar

Names

[ CAS No. ]:
618385-01-6

[ Name ]:
Vorapaxar

[Synonym ]:
Carbamic acid, [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(1E)-2-[5-(3-fluorophenyl)-2- pyridinyl]ethenyl]dodecahydro-1-methyl-3-oxonaphtho[2,3-c]furan-6-yl]-, ethyl ester
Ethyl [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)-2-pyridinyl]vinyl}-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl]carbamate
Carbamic acid, N-[(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(E)-2-[5-(3-fluorophenyl)-2-pyridinyl]ethenyl]dodecahydro-1-methyl-3-oxonaphtho[2,3-c]furan-6-yl]-, ethyl ester
Vorapaxar
UNII-ZCE93644N2
ethyl [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl}-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl]carbamate
Ethyl [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)-2- pyridinyl]vinyl}-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-y l]carbamate
Ethyl [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]vinyl}-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl]carbamate

Biological Activity

[Description]:

Vorapaxar is a protease-activated receptor (PAR-1) antagonist that inhibits thrombin-induced platelet activation.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Protease-Activated Receptor (PAR)
Research Areas >> Cardiovascular Disease

[References]

[1]. Khoufache K, et al. PAR1 contributes to influenza A virus pathogenicity in mice. J Clin Invest. 2013 Jan;123(1):206-14.

[2]. Kehinde O, et al. Vorapaxar: A novel agent to be considered in the secondary prevention of myocardial infarction. J Pharm Bioallied Sci. 2016 Apr-Jun;8(2):98-105.


[Related Small Molecules]

TRAP-6 | AZ 3451 | AC-55541 | SLIGKV-NH2 | PAR-4 (1-6) amide (mouse) trifluoroacetate salt | TFLLR-NH2 TFA | BMS-986120 | (Ala1)-PAR-4 (1-6) amide (mouse) trifluoroacetate salt | SLIGRL-NH2 2TFA | TRAP-5 trifluoroacetate salt

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
676.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C29H33FN2O4

[ Molecular Weight ]:
492.582

[ Flash Point ]:
362.6±31.5 °C

[ Exact Mass ]:
492.242432

[ PSA ]:
81.01000

[ LogP ]:
4.54

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.594

[ Storage condition ]:
-20℃

Related Compounds