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Vernolide B

Names

[ CAS No. ]:
618860-58-5

[ Name ]:
Vernolide B

[Synonym ]:
2-Butenoic acid, 2-methyl-, (4S,6R,7S,10R,11E)-3-[(acetyloxy)methyl]-2,4,5,6,7,8,9,10-octahydro-7-methoxy-6,10-dimethyl-2-oxo-7,10-epoxycyclodeca[b]furan-4-yl ester, (2E)-
(1R,2E,8S,10R,11S)-6-(Acetoxymethyl)-11-methoxy-1,10-dimethyl-5-oxo-4,14-dioxatricyclo[9.2.1.03,7]tetradeca-2,6-dien-8-yl (2E)-2-methyl-2-butenoate

Biological Activity

[Description]:

Vernolide-B has cytoxicity (ED50s: 3.78, 5.88, 6.42 μg/mL for KB, NCI-661, and HeLa cells respectively). Vernolide B is sesquiterpene lactone that can be isolated from Vernonia cinerea[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. Kuo YH, et al. Two novel sesquiterpene lactones, cytotoxic vernolide-A and -B, from Vernonia cinerea. Chem Pharm Bull (Tokyo). 2003 Apr;51(4):425-6.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
568.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C23H30O8

[ Molecular Weight ]:
434.48

[ Flash Point ]:
244.6±30.2 °C

[ Exact Mass ]:
434.194061

[ LogP ]:
3.47

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.539

Related Compounds