Phosphate Salt of Tricyclic Nucleoside

Names

[ CAS No. ]:
61966-08-3

[ Name ]:
Phosphate Salt of Tricyclic Nucleoside

[Synonym ]:
5-Methyl-1-(5-O-phosphono-b-D-ribofuranosyl)-1,5-dihydro-1,4,5,6,8-pentaazaacenaphthylen-3-amine
5-Methyl-1-(5-O-phosphono-β-D-ribofuranosyl)-1,5-dihydro-1,4,5,6,8-pentaazaacenaphthylen-3-amine
Pentaazaacenaphthylene-5' phosphate ester
3-Amino-1,5-dihydro-5-methyl-1-b-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylene 5'-(Dihydrogen Phosphate)
Phosphate Salt of Tricyclic Nucleoside
Triciribine phosphate (USAN)
1,4,5,6,8-Pentaazaacenaphthylen-3-amine, 1,5-dihydro-5-methyl-1-(5-O-phosphono-β-D-ribofuranosyl)-
VQD-002
TCN-P

Biological Activity

[Description]:

Triciribine phosphate (TCN-P) inhibits amidophosphoribosyltransferase by an allosteric mechanism which affects the first committed step of de novo purine biosynthesis. Triciribine phosphate also inhibits IMP dehydrogenase which is the first committed step of guanosine nucleotide synthesis. Tricilibine phosphate does not affect ligase activity[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> ATP Synthase

[References]

[1]. E C Moore, Inhibition of two enzymes in de novo purine nucleotide synthesis by triciribine phosphate (TCN-P). Biochem Pharmacol. 1989, 38, 22.

Chemical & Physical Properties

[ Density]:
2.2±0.1 g/cm3

[ Boiling Point ]:
832.8±75.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₃H₁₇N₆O₇P

[ Molecular Weight ]:
400.28

[ Flash Point ]:
457.4±37.1 °C

[ Exact Mass ]:
400.089630

[ PSA ]:
200.81000

[ LogP ]:
-2.83

[ Vapour Pressure ]:
0.0±3.2 mmHg at 25°C

[ Index of Refraction ]:
1.925

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RY8450000

CHEMICAL NAME :: 1,4,5,6,8-Pentaazaacenaphthylen-3-amine, 1,5-dihydro-5-methyl-1-(5-O-phosphono-beta-D- ribofuranosyl)-

CAS REGISTRY NUMBER :: 61966-08-3

LAST UPDATED :: 198605

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C13-H17-N6-O7-P

MOLECULAR WEIGHT :: 400.33

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 193 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 109 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986