Acetoacetic acid sodium salt

Names

[ CAS No. ]:
623-58-5

[ Name ]:
Acetoacetic acid sodium salt

[Synonym ]:
Butanoic acid,3-oxo-,sodium salt
sodium acetoacetic acid ester
sodium acetoxyacetate
sodium 3-oxobutanoate
sodium acetylacetonate
acetoacetic acid,monosodium salt
Sodium Acetoacetate
Acetylacetic Acid Sodium salt
Acetoacetic acid sodium salt

Biological Activity

[Description]:

Acetoacetic acid sodium salt is a metabolite of non-esterified fatty acids, involved in the development of human diabetes. Acetoacetic acid sodium salt induces oxidative stress to inhibit the assembly of very low density lipoprotein in bovine hepatocytes[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[In Vitro]

Acetoacetic acid sodium salt induces oxidative stress to inhibit the assembly of very low density lipoprotein in bovine hepatocytes[1]. Acetoacetic acid (0.6, 2.4, 4.8 mM) increases malondialdehyde (MDA) content in high-dose group (GH) group, decreases mRNA expression of Mn SOD, Cu/Zn SOD, and glutathione peroxidase (GSH-Px) in all groups, lowers catalase (CAT) mRNA expression in medial-dose group (GM), and GH groups. In addition, Acetoacetic acid down-regulates the mRNA expression of apolipoprotein B100 (ApoB100), apolipoprotein E (ApoE), and low density lipoprotein receptor (LDLR). Thus, VLDL assembly is decreased andtriglyceride (TG) accumulation is increased in these bovine hepatocytes[1].

[References]

[1]. Shi X, et al. Acetoacetic acid induces oxidative stress to inhibit the assembly of very low density lipoprotein in bovine hepatocytes. J Dairy Res. 2016 Nov;83(4):442-446.

Chemical & Physical Properties

[ Boiling Point ]:
237.7ºC at 760 mmHg

[ Molecular Formula ]:
C₄H₅NaO₃

[ Molecular Weight ]:
124.07

[ Flash Point ]:
111.8ºC

[ Exact Mass ]:
124.01400

[ PSA ]:
57.20000

Safety Information

[ HS Code ]:
2918300090

Synthetic Route

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Customs

[ HS Code ]: 2918300090

[ Summary ]:
2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%