Isopropyl 11-dodecen-1-ylphosphonofluoridate

Names

[ Name ]:
Isopropyl 11-dodecen-1-ylphosphonofluoridate

[Synonym ]:
isopropyl di-p-isopropoxyphenylphosphinite
Isopropyl 11-dodecen-1-ylphosphonofluoridate
Phosphonofluoridic acid, P-11-dodecen-1-yl-, 1-methylethyl ester

Biological Activity

[Description]:

Isopropyl dodec-11-enylfluorophosphonate (IDEFP) is an organophosphorus ester that antagonizes the central cannabinoid receptor (CB1) and inhibits FAAH with similar potencies (IC50 = 2 nM)[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> FAAH

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> FAAH

Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor

[Target]

CB1:2 μM (IC50)

[References]

[1]. Michael A Casasanta, et al. A chemical and biological toolbox for Type Vd secretion: Characterization of the phospholipase A1 autotransporter FplA from Fusobacterium nucleatum. J Biol Chem. 2017 Dec 8;292(49):20240-20254.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
351.5±11.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₃₀FO₂P

[ Molecular Weight ]:
292.370

[ Flash Point ]:
166.4±19.3 °C

[ Exact Mass ]:
292.196747

[ PSA ]:
36.11000

[ LogP ]:
5.88

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.433

Isopropyl 11-dodecen-1-ylphosphonofluoridate

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds