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L-Tyrosine (Ring-D4)

Names

[ CAS No. ]:
62595-14-6

[ Name ]:
L-Tyrosine (Ring-D4)

[Synonym ]:
(2S)-2-amino-3-(2,3,5,6-tetradeuterio-4-hydroxyphenyl)propanoic acid
L-(2,3,5,6-H)Tyrosine
L-4-Hydroxyphenyl-d4-alanine
L-TYROSINE-2,3,5,6-D4
L-4-Hydroxyphenyl-2,3,5,6-d4-alanine
MFCD00079605
L-Tyrosine-2,3,5,6-d

Biological Activity

[Description]:

L-Tyrosine D4 is a deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[In Vitro]

L-Tyrosine inhibits citrate synthase activity in the posterior cortex (2.0 and 4.0 mM), malate dehydrogenase is not altered by L-Tyrosine and succinate dehydrogenase is increased in the posterior cortex (0.1-4.0 mM), hippocampus (1.0-4.0 mM), striatum (4.0 mM) and liver (0.1-4.0 mM)[1].

[References]

[1]. Ferreira GK, et al. Effect of L-tyrosine in vitro and in vivo on energy metabolism parameters in brain and liver of young rats. Neurotox Res. 2013 May;23(4):327-35.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
385.2±32.0 °C at 760 mmHg

[ Melting Point ]:
>300ºC (dec.)(lit.)

[ Molecular Formula ]:
C9H7D4NO3

[ Molecular Weight ]:
185.213

[ Flash Point ]:
186.7±25.1 °C

[ Exact Mass ]:
185.098999

[ PSA ]:
83.55000

[ LogP ]:
0.38

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.614

[ Storage condition ]:
2-8°C

MSDS

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Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds