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Ipidacrine

Names

[ CAS No. ]:
62732-44-9

[ Name ]:
Ipidacrine

[Synonym ]:
Amiridine
Ipidacrine
9-amino-2,3,5,6,7,8-hexahydro-1-cyclopenta<b>quinoline
Amiridin

Biological Activity

[Description]:

2,3,5,6,7,8-Hexahydro-1H-cyclopenta[b]quinolin-9-amine is a pharmaceutically active compound which is a nootropic agent that acts as cholinesterase inhibitor and is used in treatment of Alzheimer disease[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> AChE

[References]

[1]. A.Dubika, K. Veldre, et al. Phase Transitions of Ipidacrine Hydrochloride Polymorphs and Hydrates. The Open Conference Proceedings Journal, 2011, 2, 21-27.

Chemical & Physical Properties

[ Density]:
1.17 g/cm3

[ Boiling Point ]:
367.969ºC at 760 mmHg

[ Molecular Formula ]:
C12H16N2

[ Molecular Weight ]:
188.26900

[ Flash Point ]:
203.991ºC

[ Exact Mass ]:
188.13100

[ PSA ]:
38.91000

[ LogP ]:
2.61250

[ Index of Refraction ]:
1.634

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GY5897400
CHEMICAL NAME :
1H-Cyclopenta(b)quinolin-9-amine, 2,3,5,6,7,8-hexahydro-
CAS REGISTRY NUMBER :
62732-44-9
BEILSTEIN REFERENCE NO. :
0475930
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C12-H16-N2
MOLECULAR WEIGHT :
188.30
WISWESSER LINE NOTATION :
TC566 BNT&TJ HZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
39 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - miosis (pupillary constriction) Behavioral - tremor Gastrointestinal - hypermotility, diarrhea
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 11,184,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
52 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 23,709,1989

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Precursor & DownStream


Related Compounds