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Jolkinol A

Names

[ CAS No. ]:
62820-11-5

[ Name ]:
Jolkinol A

[Synonym ]:
(1aR,1bR,2S,3S,4aR,6E,7aR,8aS,10aR)-2-Hydroxy-6-(hydroxymethyl)-3,8,8,10a-tetramethyl-5-oxo-1a,1b,2,3,4,5,7a,8,8a,9,10,10a-dodecahydro-4aH-cyclopenta[10,11]cyclopropa[5,6]cycloundeca[1,2-b]oxiren-4a-yl (2E)-3-phenylacrylate
Jolkinol A
2-Propenoic acid, 3-phenyl-, (1aR,1bR,2S,3S,4aR,6E,7aR,8aS,10aR)-1a,1b,2,3,4,5,7a,8,8a,9,10,10a-dodecahydro-2-hydroxy-6-(hydroxymethyl)-3,8,8,10a-tetramethyl-5-oxo-4aH-cyclopenta[10,11]cyclopropa[5,6]cycloundec[1,2-b]oxiren-4a-yl ester, (2E)-

Biological Activity

[Description]:

Jolkinol A is a natural product that can be found in Euphorbia pubescens. Jolkinol A inhibits cell growth with GI50s of 95.3, 57.3, >100 µM for MCF-7, NCI-460, SF-268 cells, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. Valente C, et al. Euphopubescenol and euphopubescene, two new jatrophane polyesters, and lathyrane-type diterpenes from Euphorbia pubescens. Planta Med. 2004 Mar;70(3):244-9.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
643.1±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C29H36O6

[ Molecular Weight ]:
480.592

[ Flash Point ]:
210.1±25.0 °C

[ Exact Mass ]:
480.251190

[ PSA ]:
96.36000

[ LogP ]:
4.87

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.605

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds