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NSC10010 hydrochloride

Names

[ CAS No. ]:
6286-09-5

[ Name ]:
NSC10010 hydrochloride

Biological Activity

[Description]:

NSC10010 hydrochloride inhibits gammaherpesvirus associated B-lymphomas growth through activation of NF-kB and c-Myc-mediated signaling pathways. NSC10010 hydrochloride induces necrotic cell death in gammaherpesvirus infected B-cells. NSC10010 hydrochloride is also an inhibitor of Mtb ClpC1 ATPase[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Anti-infection >> HSV
Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Dzeng RK, et al. Small molecule growth inhibitors of human oncogenic gammaherpesvirus infected B-cells. Mol Oncol. 2015 Feb;9(2):365-76.  

[2]. Amritansh Bhanot, et al. Discovery of small molecule inhibitors of Mycobacterium tuberculosis ClpC1: SAR studies and antimycobacterial evaluation. Results in Chemistry. Volume 5, January 2023, 100904.

Chemical & Physical Properties

[ Density]:
1.137g/cm3

[ Boiling Point ]:
674.2ºC at 760 mmHg

[ Molecular Formula ]:
C31H41ClN4O2

[ Molecular Weight ]:
537.13600

[ Flash Point ]:
361.5ºC

[ Exact Mass ]:
536.29200

[ PSA ]:
68.30000

[ LogP ]:
8.61970

[ Index of Refraction ]:
1.632

Related Compounds