<Suppliers Price>

NSC31205

Names

[ CAS No. ]:
6320-51-0

[ Name ]:
NSC31205

[Synonym ]:
5-(4-methoxy-benzylidene)-thiazolidine-2,4-dione
5-(4-methoxybenzylidene)-2,4-thiazolidinedione
(Z)-5-(4-methoxybenzylidene)-2,4-thiazolidinedione
(Z)-5-4-(methoxybenzylidene)thiazolidine-2,4-dione
2,4-Thiazolidinedione,5-p-methoxybenzylidene
(5Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione
(Z)-5-(4-methoxyphenylmethylene)-2,4-thiazolidinedione

Biological Activity

[Description]:

Pim-1/2 kinase inhibitor 1 is an orally active pim-1/2 kinase inhibitor. Pim-1/2 kinase inhibitor 1 blocks the ability of Pim kinases to phosphorylate peptides, and inhibits the pim protein kinase directed phosphorylation of 4E-BP1 and p27Kip1. Pim-1/2 kinase inhibitor 1 can be used in study of cancer, especially prostate cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> Pim

[In Vitro]

Pim-1/2 kinase inhibitor 1 (compound D14) (varying concentrations; 48 h) shows cytotoxicity to PC3 cells, with an IC of 11 µM[1]. Cell Cytotoxicity Assay[1] Cell Line: PC3 cells Concentration: varying concentrations Incubation Time: 48 h Result: Inhibited PC3 cells with an IC of 11 µM.

[References]

[1]. Charles D. Smith, et al. Inhibitors of PIM-1 Protein Kinases, Compositions and Methods for Treating Prostate Cancer. Patent US20110263664A1.

Chemical & Physical Properties

[ Density]:
1.391g/cm3

[ Molecular Formula ]:
C11H9NO3S

[ Molecular Weight ]:
235.25900

[ Exact Mass ]:
235.03000

[ PSA ]:
80.70000

[ LogP ]:
2.34790

[ Index of Refraction ]:
1.667

[ Storage condition ]:
-20℃

Related Compounds