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KW-6055

Names

[ CAS No. ]:
63233-46-5

[ Name ]:
KW-6055

[Synonym ]:
N-(3-Nitro-4-(2-pyridinylmethyl)phenyl)butanamide
2-(4-Butyrylamino-2-nitrobenzyl)pyridine
KW 6055
Butanamide,N-(3-nitro-4-(2-pyridinylmethyl)phenyl)
KW-6055

Biological Activity

[Description]:

KW-6055 is a benzylpyridine derivative and has anti-amnesic activity.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[In Vivo]

KW-6055 is a benzylpyridine derivative and has anti-amnesic activity. KW-6055 (40, 160 mg/kg, p.o.) increases the extracellular level of ACh in normal rats (257±23, 202±24%). In basal forebrain-lesioned rats, KW-6055 (40 mg/kg, p.o.) significantly increases the extracellular level of ACh (251±22%) for more than 2 hr, which is longer than in normal rats[1].

[References]

[1]. Kurokawa M, et al. Effects of KW-6055, a novel benzylpyridine derivative, on central cholinergic systems. Nihon Yakurigaku Zasshi. 1992 Jun;99(6):435-43.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Density]:
1.247g/cm3

[ Boiling Point ]:
492.6ºC at 760mmHg

[ Molecular Formula ]:
C16H17N3O3

[ Molecular Weight ]:
299.32400

[ Flash Point ]:
251.7ºC

[ Exact Mass ]:
299.12700

[ PSA ]:
91.30000

[ LogP ]:
4.49190

[ Storage condition ]:
2-8℃

Related Compounds