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Aivlosin

Names

[ CAS No. ]:
63409-12-1

[ Name ]:
Aivlosin

[Synonym ]:
O3'-Acetyl-2'-desoxy-adenosin
3'-O-Acetyl-2'-deoxyadenosin
2'-deoxy-3'-O-acetyladenosine
O3'-acetyl-2'-deoxy-adenosine
3-O-acetyl-4"-O-isovaleryltylosin
2'-Deoxyadenosine 3'-acetate
3-acetate 4B-(3-methylbutanoate)
3'-O-Acetyl-2'-desoxyadenosin

Biological Activity

[Description]:

Tylvalosin (Acetylisovaleryltylo?sin) is a broad-spectrum macrolide antibiotic that has antibacterial activity. Tylvalosin is an antiviral agent and can be used for PRRSV infection. . Tylvalosin induces apoptosis. Tylvalosin also has anti-inflammatory activity, relieves oxidative stress, and relieves acute lung injury by suppression of NF-κB activation[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Infection
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Albert Philip Adrian Mockett, et al. Use of tylvalosin as antiviral agent. Patent. WO2008007104.

[2]. Zhao Z, et al. Tylvalosin exhibits anti-inflammatory property and attenuates acute lung injury in different models possibly through suppression of NF-κB activation. Biochem Pharmacol. 2014 Jul 1;90(1):73-87.  

[3]. Moges R, et al. Anti-Inflammatory Benefits of Antibiotics: Tylvalosin Induces Apoptosis of Porcine Neutrophils and Macrophages, Promotes Efferocytosis, and Inhibits Pro-Inflammatory CXCL-8, IL1α, and LTB4 Production, While Inducing the Release of Pro-Resolving Lipoxin A4 and Resolvin D1. Front Vet Sci. 2018 Apr 11;5:57.  

Chemical & Physical Properties

[ Density]:
1.21g/cm3

[ Boiling Point ]:
1005.4ºC at 760 mmHg

[ Melting Point ]:
>105°C (dec.)

[ Molecular Formula ]:
C53H87NO19

[ Molecular Weight ]:
1042.25

[ Flash Point ]:
561.8ºC

[ Exact Mass ]:
1041.59000

[ PSA ]:
250.81000

[ LogP ]:
4.00130

[ Index of Refraction ]:
1.534

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream