D-(+)-Malic acid

Names

[ CAS No. ]:
636-61-3

[ Name ]:
D-(+)-Malic acid

[Synonym ]:
Malic acid, D-
(R)-Hydroxybutanedioic acid
Butanedioic acid, 2-hydroxy-, (2R)-
EINECS 211-262-2
(R)-(+)-HYDROXYSUCCINIC ACID
Malic acid,D
R-Malic acid
D-malate
D-Malic Acid
(R)-2-Hydroxysuccinic acid
(R)-2-Hydroxy-succinic acid
(2R)-2-hydroxybutanedioic acid
2(R)-hydroxybutanedioic acid
(2R)-2-Hydroxysuccinic acid
L-malic acid
(R)-malic acid
D-(+)-Malic Acid
D-Hydroxybutanedioic acid
MFCD00004245
D(+)-Malic acid

Biological Activity

[Description]:

D-(+)-Malic acid (D-Malic acid), an active enantiomer of Malic acid, is a competitive inhibitor of L(--)malic acid transport[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[In Vitro]

Some bacteria belonging to Arthrobacter, Brevibacterium, Corynebacterium, Pseudomonas, Bacillus, and Acinetobacter produced D-(+)-Malic acid (D-Malic acid) from Maleic acid when the cells grown in a medium containing citraconic acid are reacted aerobically with Maleic acid in the pH 7.0 phosphate buffer containing 0.1% sodium chloride[2].

[References]

[1]. Manuela Côrte-Real, et al. Transport of L(-)malic acid and other dicarboxylic acids in the yeast Candida sphaerica. Appl Microbiol Biotechnol (1989) 31:551-555.

[2]. Kiyoshi Nakayama, et al. D-malic acid production from maleic acid using microorganism: Screening of microorganism. Biotechnology Letters volume 15, 271–276(1993).

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
306.4±27.0 °C at 760 mmHg

[ Melting Point ]:
98-104ºC

[ Molecular Formula ]:
C₄H₆O₅

[ Molecular Weight ]:
134.087

[ Flash Point ]:
153.4±20.2 °C

[ Exact Mass ]:
134.021530

[ PSA ]:
94.83000

[ LogP ]:
-1.26

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.529

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ON7260000

CHEMICAL NAME :: Malic acid, L(+)-

CAS REGISTRY NUMBER :: 636-61-3

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C4-H6-O5

MOLECULAR WEIGHT :: 134.10

WISWESSER LINE NOTATION :: QVYQ1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 5500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IECHAD Industrial and Engineering Chemistry. (Washington, DC) V.15-62, 1923-70. For publisher information, see CHMTBL. Volume(issue)/page/year: 15,628,1923

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H315-H318-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
ON7260000

[ HS Code ]:
29181980

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918199090

[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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