Pramoxine HCl
Names
[ CAS No. ]:
637-58-1
[ Name ]:
Pramoxine HCl
[Synonym ]:
p-Butoxyphenyl g-Morpholinopropyl Ether Hydrochloride
proctofoam
p-Butoxyphenyl γ-morpholinopropyl ether hydrochloride
g-Morpholinopropyl 4-n-Butoxyphenyl Ether Hydrochloride
Morpholine, 4-[3- (4-butoxyphenoxy)propyl]-, hydrochloride
EINECS 211-293-1
γ-Morpholinopropyl 4-N-butoxyphenyl ether hydrochloride
Morpholine, 4-[3- (p-butoxyphenoxy)propyl]-, hydrochloride
Pramoxine hydrochloride
4-[3-(4-Butoxyphenoxy)propyl]morpholine Hydrochloride
Tronothane hydrochloride
4-[3-(4-Butoxyphenoxy)propyl]morpholine hydrochloride (1:1)
pramoxine HCl
4-[3-(p-Butoxyphenoxy)propyl]morpholine hydrochloride
MFCD00054323
Proxazocain Hydrochloride
4-[3-(4-butoxyphenoxy)propyl]morpholine,hydrochloride
Morpholine, 4-[3-(4-butoxyphenoxy)propyl]-, hydrochloride (1:1)
Pramocaine (hydrochloride)
Biological Activity
[Description]:
[Related Catalog]:
[Related Small Molecules]
Chemical & Physical Properties
[ Boiling Point ]:
427ºC at 760 mmHg
[ Melting Point ]:
181-183ºC
[ Molecular Formula ]:
C17H28ClNO3
[ Molecular Weight ]:
329.862
[ Flash Point ]:
123.5ºC
[ Exact Mass ]:
329.175781
[ PSA ]:
30.93000
[ LogP ]:
3.70650
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QD8750000
- CHEMICAL NAME :
- Morpholine, 4-(3-(p-butoxyphenoxy)propyl)-, hydrochloride
- CAS REGISTRY NUMBER :
- 637-58-1
- LAST UPDATED :
- 199504
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C17-H27-N-O3.Cl-H
- MOLECULAR WEIGHT :
- 329.91
- WISWESSER LINE NOTATION :
- T6N DOTJ A3OR DO4 &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1050 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,99,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 460 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,99,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1470 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Cardiac - cardiac output Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- AAREAV Anesthesie, Analgesie, Reanimation. (Paris, France) V.14-38, 1957-81. Volume(issue)/page/year: 14,225,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 79500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 1,454,1959
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 39 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,99,1969
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 109 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Cardiac - cardiac output Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- AAREAV Anesthesie, Analgesie, Reanimation. (Paris, France) V.14-38, 1957-81. Volume(issue)/page/year: 14,225,1957 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80493 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80493 No. of Facilities: 98 (estimated) No. of Industries: 2 No. of Occupations: 11 No. of Employees: 16892 (estimated) No. of Female Employees: 15582 (estimated)
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi:Irritant
[ Risk Phrases ]:
R22;R36/37/38
[ Safety Phrases ]:
S26-S36
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
QD8750000
[ HS Code ]:
2934999090
Customs
[ HS Code ]: 2934999090
[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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