ANO1-IN-2

Names

[ CAS No. ]:
637314-12-6

[ Name ]:
ANO1-IN-2

Biological Activity

[Description]:

ANO1-IN-2 (Compound 10q) is a selective ANO1 channel blocker with an IC50 of 1.75 μM and 7.43 μM against ANO1 and ANO2, respectively. ANO1-IN-2 suppresses strongly proliferation of glioblastoma cells[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Membrane Transporter/Ion Channel >> Chloride Channel

[Target]

IC50: 1.75 μM (ANO1), 7.43 μM (ANO2)[1]


[In Vitro]

ANO1-IN-2 (Compound 10q) (10 μM) significantly suppresses migration and invasion of U251 cells[1].

[References]

[1]. Choi SH, et al. Anti-glioma effects of 2-aminothiophene-3-carboxamide derivatives, ANO1 channel blockers. Eur J Med Chem. 2020 Dec 15;208:112688.

Chemical & Physical Properties

[ Molecular Formula ]:
C16H14ClN3O2S2

[ Molecular Weight ]:
379.88

Related Compounds