Indalpine

Names

[ Name ]:
Indalpine

[Synonym ]:
EINECS 264-445-4
Lipstene
INDALPINE
LM 5008

Biological Activity

[Description]:

Indalpine (LM 5008) is a potent and selective 5-HT uptake blocker. Indalpine is potent in displacing 3H-5-HT bound to brain membranes with the IC50 of 36 μM[1]. Indalpine, two antidepressant agent[2].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> Serotonin Transporter

[In Vivo]

In keeping with its potent reuptake-blocking property, acute IV Indalpine produces a marked decrease in the firing rate of dorsal raphe 5-HT neurons (ED50 0.33 mg/kg). The firing rate of dorsal raphe 5-HT neurons is assessed following 2-, 7- and 14-day treatments with Indalpine (5 mg/day IP). After 2 days, the firing rate of 5-HT neurons is greatly reduced, after 7 days it has recovered partially and after 14 days it has returned to normal[2].

[References]

[1]. R Samanin, et al. Further studies on the mechanism of serotonin-dependent anorexia in rats. Psychopharmacology (Berl). 1980;68(1):99-104.

[2]. P Blier, et al. Effects of the two antidepressant drugs mianserin and Indalpine on the serotonergic system: single-cell studies in the rat. Psychopharmacology (Berl). 1984;84(2):242-9.

Chemical & Physical Properties

[ Density]:
1.07 g/cm3

[ Boiling Point ]:
405.1ºC at 760 mmHg

[ Molecular Formula ]:
C₁₅H₂₀N₂

[ Molecular Weight ]:
228.33300

[ Flash Point ]:
198.8ºC

[ Exact Mass ]:
228.16300

[ PSA ]:
27.82000

[ LogP ]:
3.42890

[ Index of Refraction ]:
1.595

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NM1303800

CHEMICAL NAME :: 1H-Indole, 3-(2-(4-piperidinyl)ethyl)-

CAS REGISTRY NUMBER :: 63758-79-2

BEILSTEIN REFERENCE NO. :: 0612584

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C15-H20-N2

MOLECULAR WEIGHT :: 228.37

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Rodent - rat Liver

DOSE/DURATION :: 500 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 221,263,1989

Safety Information

[ RIDADR ]:
UN 3249

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%