CID-2011756

Names

[ Name ]:
CID-2011756

[Synonym ]:
QCR-12
5-(3-Chlorophenyl)-N-[4-(4-morpholinylmethyl)phenyl]-2-furamide
HMS2426M13
2-Furancarboxamide, 5-(3-chlorophenyl)-N-[4-(4-morpholinylmethyl)phenyl]-
cc-693
CID-2011756
CID 2011756

Biological Activity

[Description]:

CID 2011756 is an ATP competitive PKD inhibitor, with an IC50 of 3.2 µM for PKD1 in cell free assay, and also shows cellular pan-PKD inhibitory activity against PKD2 and PKD3 (IC50, 0.6 and 0.7 µM, respectively). CID 2011756 also has antitumor activity.

[Related Catalog]:

Signaling Pathways >> Apoptosis >> PKD

Research Areas >> Cancer

[Target]

Cellular PKD2:0.6 μM (IC50)

Cellular PKD3:0.7 μM (IC50)

PKD1:3.2 μM (IC50)

[In Vitro]

CID 2011756 is an ATP-competitive PKD1 inhibitor, with an IC50 of 3.2 µM. CID 2011756 decreases the phosphorylation of endogenous PKD1 Ser916 in LNCaP cancer cells with an EC50 of 10±0.7 µM. CID 2011756 also has cellular pan-PKD inhibitory effects, with IC50s of 0.6±0.1 µM and 0.7±0.2 µM for PKD2 and PKD3, respectively[1].

[References]

[1]. Sharlow ER, et al. Discovery of diverse small molecule chemotypes with cell-based PKD1 inhibitory activity. PLoS One. 2011;6(10):e25134.

[Related Small Molecules]

1-NM-PP1 | CID755673 | CRT0066101 | kb-NB142-70

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
491.0±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₁ClN₂O₃

[ Molecular Weight ]:
396.867

[ Flash Point ]:
250.8±28.7 °C

[ Exact Mass ]:
396.124084

[ PSA ]:
58.20000

[ LogP ]:
3.69

[ Appearance of Characters ]:
white solid

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.633

[ Storage condition ]:
-20℃

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport