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AGL-2263

Names

[ CAS No. ]:
638213-98-6

[ Name ]:
AGL-2263

[Synonym ]:
(2E)-2-(3,4-Dihydroxybenzoyl)-3-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)acrylonitrile
Benzenepropanenitrile, α-[(2,3-dihydro-2-oxo-5-benzoxazolyl)methylene]-3,4-dihydroxy-β-oxo-, (αE)-

Biological Activity

[Description]:

AGL-2263 is an insulin receptor (IR) blocker.

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Insulin Receptor
Research Areas >> Metabolic Disease

[Target]

Insulin receptor[1].


[In Vitro]

AGL-2263 is an insulin receptor (IR) blocker[1].

[Cell Assay]

Trophoblast cells are prepared from normal or GDM placentas. They are incubated in the presence of stimulants, insulin (100 nM) or both insulin and AGL-2263 (AGL, 5 μM) IR blocker, together for 24 hr[1].

[References]

[1]. Li Y, et al. GDM-associated insulin deficiency hinders the dissociation of SERT from ERp44 and down-regulates placental 5-HT uptake. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):E5697-705.


[Related Small Molecules]

Insulin(human) | OSI-906(Linsitinib) | Insulin(cattle) | BMS-754807 | NVP-AEW541 | BMS-536924 | NT157 | GSK1838705A | CAY10415 | KU14R | Insulin levels modulator | Kaempferitrin

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C17H10N2O5

[ Molecular Weight ]:
322.272

[ Exact Mass ]:
322.058960

[ LogP ]:
1.72

[ Index of Refraction ]:
1.728

[ Storage condition ]:
2-8℃

Related Compounds