Etimizol

Names

[ CAS No. ]:
64-99-3

[ Name ]:
Etimizol

[Synonym ]:
aethimizolum
Ethimizol
Ethymisol
1-ethyl-1H-imidazole-4,5-dicarboxylic acid bis-methylamide
Ethymysol
1 ethyl 4,5 bis(methylcarbamoyl)imidazole
Ethylnorantefein
Etimyzol
1-ethyl-4,5-di(N-methylcarbamoyl)-imidazole
Antiffine
Ethimizole
Ethymisole
1-ethylimidazole-4,5-dicarboxylic acid di(methylamide)
Ethymazol
ETIMIZOL

Biological Activity

[Description]:

Etimizol(Ethymisole; Antiffine; Ethylnorantifein) was shown to relieve amnesia effectively in the origin of which there is the hypoxic component (hypobaric hypoxia, actinomycin D, mechanical injury of the brain). IC50 Value: Target: Etimizol has a catalytic effect on the respiratory center and belongs to the group of respiratory analeptics, however, it activates adrenokortikotropnuyu pituitary function, which leads to increased levels of glucocorticosteroids in the blood. There is also evidence that short etimizol improves memory and increases mental performance.in vitro:in vivo: The time interval between administration ofetimizol (3 mg/kg) and the onset of learning varied between 0.5 and 3 h in the several series. Etimizol did not facilitate the learning in rats whatever the time of administration and biological modality of reinforcement [1]. After administration of etimizol at doses of 10 or 1 mg/loop mean residence time of etimizol in the loop was 20.1 and 7.6 min, respectively, with mean standard deviation being 3.1 and 0.8, respectively [2]. Extracellular application of 5--10 mM/L etimizol exerted a specific effect on the giant neurons of the Coretus corneus isolated nervous system: action potential duration increased significantly, speed of development of its descending phase decreased, as well as the trace hyperpolarization amplitude [3].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Natural Products >> Alkaloid

Research Areas >> Neurological Disease

[References]

[1]. Borisova GIu. Effect of etimizol on instrumental learning in rats. Biull Eksp Biol Med. 1985 Jun;99(6):705-6.

[2]. Trnovec T, et al. Etimizol absorption from the small intestine in dogs: the dependence on dosage. Biull Eksp Biol Med. 1986 Dec;102(12):729-30.

[3]. Vislobokov AI, et al. Elektrophysiological parameters of mollusk neurons under the influence of etimizol. Fiziol Zh SSSR Im I M Sechenova. 1975 Jun;61(6):917-24.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.26g/cm3

[ Boiling Point ]:
563.4ºC at 760 mmHg

[ Molecular Formula ]:
C₉H₁₄N₄O₂

[ Molecular Weight ]:
210.23300

[ Flash Point ]:
294.5ºC

[ Exact Mass ]:
210.11200

[ PSA ]:
83.00000

[ LogP ]:
0.77180

[ Index of Refraction ]:
1.586

[ Storage condition ]:
-20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI4750500

CHEMICAL NAME :: 1H-Imidazole-4,5-dicarboxamide, 1-ethyl-N,N'-dimethyl-

CAS REGISTRY NUMBER :: 64-99-3

BEILSTEIN REFERENCE NO. :: 0525707

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H14-N4-O2

MOLECULAR WEIGHT :: 210.27

WISWESSER LINE NOTATION :: T5N CNJ A2 DVM1 EVM1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 20,99,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 42,221,1979

Safety Information

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%