Boc-6-aminohexanoic acid

Names

[ Name ]:
Boc-6-aminohexanoic acid

[Synonym ]:
6-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)hexanoic acid
6-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid
6-[(tert-butoxycarbonyl)amino]hexanoic acid
Hexanoic acid, 6-[[(1,1-dimethylethoxy)carbonyl]amino]-
MFCD00037798
Boc-ε-Acp-OH
Boc-ε-Ahx-OH

Biological Activity

[Description]:

Boc-6-aminohexanoic acid is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
380.3±25.0 °C at 760 mmHg

[ Melting Point ]:
35-40 °C

[ Molecular Formula ]:
C₁₁H₂₁NO₄

[ Molecular Weight ]:
231.289

[ Flash Point ]:
183.8±23.2 °C

[ Exact Mass ]:
231.147064

[ PSA ]:
75.63000

[ LogP ]:
1.67

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.464

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
S22-S24/25-S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2924199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

The literature on affinity chromatography.

Meth. Enzymol. 34 , 3, (1974)

Affinity chromatography of carboxypeptidase B.

Meth. Enzymol. 34 , 411, (1974)

Synthesis and properties of radioiodinated phospholipid analogues that spontaneously undergo vesicle-vesicle and vesicle-cell transfer.

Biochemistry 22 , 3617, (1983)

An efficient method for the synthesis and purification of a variety of iodinated phospholipid analogues is described. 1-Acyl-2-[[[3-(3-[125I]iodo-4-hydroxyphenyl)- propionyl]amino]caproyl]phosphatidyl...