1-((4-Nitrophenyl)sulfonyl)piperidine

Names

[ Name ]:
1-((4-Nitrophenyl)sulfonyl)piperidine

[Synonym ]:
1-(4-nitrophenyl)sulfonylpiperidine

Biological Activity

[Description]:

VP-4509, an anti-methicillin‐resistant Staphylococcus aureus (MRSA) agent, with the MIC of 49.3 µM. VP-4509 also possesses high antibacterial activity towards gram-negative bacteria P. aeruginosa[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Palchykov V, et, al. Antimicrobial action of arylsulfonamides bearing (aza)norbornane and related motifs: evaluation of new promising anti-MRSA agents. Medicinal Chemistry Research volume 31, pages284-292 (2022).

Chemical & Physical Properties

[ Density]:
1.374g/cm3

[ Boiling Point ]:
435.9ºC at 760 mmHg

[ Melting Point ]:
166ºC

[ Molecular Formula ]:
C₁₁H₁₄N₂O₄S

[ Molecular Weight ]:
270.30500

[ Flash Point ]:
217.4ºC

[ Exact Mass ]:
270.06700

[ PSA ]:
91.58000

[ LogP ]:
3.31130

[ Index of Refraction ]:
1.592

MSDS

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Safety Information

[ HS Code ]:
2935009090

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%