FF-MAS

Names

[ Name ]:
FF-MAS

[Synonym ]:
(3R,5S,10S,13S,17S)-4,4,10,13-tetramethyl-17-[(2R)-6-methylhept-5-en-2-yl]-1,2,3,5,6,7,11,12,16,17-decahydrocyclopenta[a]phenanthren-3-ol
(3β,5α)-4,4-Dimethylcholesta-8,14,24-trien-3-ol
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol

Biological Activity

[Description]:

FF-MAS is a potent meiotic maturation agonist. FF-MAS promotes meiotic maturation and preimplantation development of mouse oocytes maturing in vitro. FF-MAS promotes the completion of meiotic maturation to metaphase II (MII) and improves competence to complete the 2-cell stage to blastocyst transition[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[In Vitro]

FF-MAS (1 µM；16-17 小时) 促进减数分裂成熟的完成和卵母细胞完成从 2 细胞阶段到囊胚转变的能力[1]。

[References]

[1]. Marín Bivens CL, et al. A synthetic analogue of meiosis-activating sterol (FF-MAS) is a potent agonist promoting meiotic maturation and preimplantation development of mouse oocytes maturing in vitro. Hum Reprod. 2004 Oct;19(10):2340-4.

[2]. Thorsten Blume, et al. Two Syntheses of FF-MAS. Org. Lett. 2003, 5, 11, 1837-1839.

Chemical & Physical Properties

[ Density]:
1g/cm3

[ Boiling Point ]:
512.6ºC at 760 mmHg

[ Molecular Formula ]:
C₂₉H₄₆O

[ Molecular Weight ]:
410.67500

[ Flash Point ]:
221.9ºC

[ Exact Mass ]:
410.35500

[ PSA ]:
20.23000

[ LogP ]:
8.00910

[ Index of Refraction ]:
1.541

FF-MAS

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds