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HepIn-13

Names

[ CAS No. ]:
64369-13-7

[ Name ]:
HepIn-13

[Synonym ]:
1h-naphth[1,2-e][1,3]oxazine,2-(4-bromophenyl)-2,3-dihydro
2-(4-bromo-phenyl)-2,3-dihydro-1H-perimidine
2-<4-Brom-phenyl>-2.3-dihydro-1H-naphth<1.2-e>-1.3-oxazin
2-(4-bromo-phenyl)-2,3-dihydro-1H-naphth[1,2-e][1,3]oxazine
2-(4-bromophenyl)-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazine

Biological Activity

[Description]:

Hepln-13 is a potent and orally active Hepsin inhibitor with an IC50 of 0.33 µM. Hepln-13 can be used for the research of metastatic prostate cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[Target]

IC50: 0.33 μM (Hepsin)


[In Vitro]

Hepln-13 (10 µM; 2 hours; 293 cells) inhibits cleavage[1]. Western Blot Analysis[1] Cell Line: 293 cells Concentration: 10 µM Incubation Time: 2 hours Result: Inhibited cleavage.

[In Vivo]

HepIn-13 displays dose dependent inhibition of Hepsin overexpression-relevant prostate cancer phenotypes and blocks prostate cancer metastasis[1].

[References]

[1]. Tang X, et al. Targeted inhibition of cell-surface serine protease Hepsin blocks prostate cancer bone metastasis. Oncotarget. 2014;5(5):1352-1362.

Chemical & Physical Properties

[ Density]:
1.444g/cm3

[ Boiling Point ]:
533.3ºC at 760 mmHg

[ Molecular Formula ]:
C17H13BrN2

[ Molecular Weight ]:
325.20300

[ Flash Point ]:
276.4ºC

[ Exact Mass ]:
324.02600

[ PSA ]:
24.06000

[ LogP ]:
5.41450

[ Index of Refraction ]:
1.688

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds