6,7-Dimethoxy-2,2-dimethylchromene

Names

[ CAS No. ]:
644-06-4

[ Name ]:
6,7-Dimethoxy-2,2-dimethylchromene

[Synonym ]:
2H-1-BENZOPYRAN,6,7-DIMETHOXY-2,2-DIMETHYL
6,7-dimethoxy-2,2-dimethyl-3-chromene
EINECS 211-408-5
6,7-Dimethoxy-2,2-dimethyl-2H-1-benzopyran
precocenes II
2H-1-Benzopyran, 6,7-dimethoxy-2,2-dimethyl-
6,7-Dimethoxy-2,2-dimethyl2H-1-benzopyran
6,7-Dimethoxy-2,2-dimethyl-2H-benzopyran
6,7-Dimethoxy-2,2-dimethylchromene
6,7-Dimethoxy-2,2-dimethyl-2H-chromene
PRICOCENE II
Ageratochromene
Precocen 2
6,7-dimethoxy-2,2-dimethylchrom-3-ene
Precocene 2

Biological Activity

[Description]:

Precocene II is the insect antijuvenile hormone[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Ohta T, et al. Radiosynthesis and metabolism of the insect antijuvenile hormone, precocene II. J Agric Food Chem. 1977;25(3):478-481.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
300.4±42.0 °C at 760 mmHg

[ Melting Point ]:
47.5ºC

[ Molecular Formula ]:
C₁₃H₁₆O₃

[ Molecular Weight ]:
220.26

[ Flash Point ]:
100.0±25.2 °C

[ Exact Mass ]:
220.109940

[ PSA ]:
27.69000

[ LogP ]:
3.38

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.514

[ Storage condition ]:
-20°C Freezer

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ2527000

CHEMICAL NAME :: 2H-1-Benzopyran, 6,7-dimethoxy-2,2-dimethyl-

CAS REGISTRY NUMBER :: 644-06-4

BEILSTEIN REFERENCE NO. :: 0160683

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C13-H16-O3

MOLECULAR WEIGHT :: 220.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg/5D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes primarily in glomeruli Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - hematuria

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 27536 ug/kg

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: Specific locus test

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Rodent - rat Liver

DOSE/DURATION :: 1 umol/L

REFERENCE :: CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 26,311,1985

Safety Information

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S24/25

[ RTECS ]:
DJ2527000

[ HS Code ]:
2909199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2909199090

[ Summary ]:
2909199090. other acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%