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Demethylwedelolactone

Names

[ CAS No. ]:
6468-55-9

[ Name ]:
Demethylwedelolactone

[Synonym ]:
6H-Benzofuro[3,2-c][1]benzopyran-6-one, 1,3,8,9-tetrahydroxy-
6H-Benzofuro(3,2-c)(1)benzopyran-6-one, 1,3,8,9-tetrahydroxy-
1,3,8,9-Tetrahydroxy-6H-[1]benzofuro[3,2-c]chromen-6-one
demethylwedelolactone

Biological Activity

[Description]:

Demethylwedelolactone is a naturally occurring coumestan isolated from Eclipta alba. Demethylwedelolactone is a potent trypsin inhibitor with an IC50 of 3.0 μM. Demethylwedelolactone suppresses cell motility and cell invasion of breast cancer cell[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[Target]

IC50: 3.0 μM (trypsin)[1]


[References]

[1]. Syed SD, et al. Trypsin inhibitory effect of wedelolactone and demethylwedelolactone. Phytother Res. 2003 Apr;17(4):420-1.

[2]. Lee YJ, et al. Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice. Eur J Med Chem. 2012 Oct;56:361-7.

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
531.4±35.0 °C at 760 mmHg

[ Melting Point ]:
360ºC

[ Molecular Formula ]:
C15H8O7

[ Molecular Weight ]:
300.220

[ Flash Point ]:
275.2±25.9 °C

[ Exact Mass ]:
300.027008

[ PSA ]:
124.27000

[ LogP ]:
1.79

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.847

[ Storage condition ]:
2-8℃

Safety Information

[ HS Code ]:
2932999099

Synthetic Route

Precursor & DownStream

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%


Related Compounds