Granuliberin-R

Names

[ Name ]:
Granuliberin-R

[Synonym ]:
granuliberin r

Biological Activity

[Description]:

Granuliberin R is a new mast cell degranulating peptide comes from amphibian, can be isolated from the skin of frog Rana rugosa. Granuliberin R is a dodecapeptide, can act on rat peritoneal mast cell to liberate granules and release histamine[1][2].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor

Research Areas >> Endocrinology

Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[In Vitro]

Granuliberin R (10 μg/mL) does not alter the release of catecholamines and adenine nucleotides from cultured adrenal chromaffin cells, while the Mastoparan (10 μg/mL) increases both of them[3].

[In Vivo]

Granuliberin R (0.1 mg/mL, 1 μg/mL, and 10 ng/mL; injection; single dose for 60 s) interfere in the proliferation of oral keratinocytes and the activity of connective tissue cells when treatment is conducted into rats mandibular gingiva in the vicinity of the right mental foramen[4].

[References]

[1]. Nakajima T, et al. A new mast cell degranulating peptide, granuliberin-R, in the frog (Rana rugosa) skin. Chem Pharm Bull (Tokyo). 1977 Sep;25(9):2464-5.

[2]. Yasuhara T, et al. The studies on the active peptide in the skin of Rana rugosa. II. The structure of ranatensin-R, the new ranatensin analogue, and granuliberin-R, the new mast cell degranulating peptide. Chem Pharm Bull (Tokyo). 1979 Feb;27(2):492-8.

[3]. Vitale N, et al. Exocytosis in chromaffin cells: evidence for a MgATP-independent step that requires a pertussis toxin-sensitive GTP-binding protein. Biochem J. 1994 May 15;300 ( Pt 1)(Pt 1):217-27.

[4]. Kozakiewicz M, et al. Modulation of the mitotic activity and population of the mast cells in the oral mucosa by substance P. Cell Mol Biol Lett. 2003;8(3):727-34.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆₉H₁₀₃N₁₉O₁₄

[ Molecular Weight ]:
1422.68000

[ Exact Mass ]:
1421.79000

[ PSA ]:
535.89000

[ LogP ]:
4.01660

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3.0

Precursor & DownStream

Precursor

DownStream

Articles

A new mast cell degranulating peptide, granuliberin-R, in the frog (Rana rugosa) skin.

Chem. Pharm. Bull. 25 , 2464, (1977)

Synthesis of granuliberin-R and various fragment peptides and their histamine-releasing activities.

Chem. Pharm. Bull. 28(3) , 887-92, (1980)

Immunocytochemical localization of a granuliberin-like peptide in Rana pipiens brain.

Neuroscience 12(1) , 329-37, (1984)

The histamine-releasing peptide "granuliberin", originally isolated from the skin of Rana rugosa, was localized by immunofluorescence within nerve cell bodies and fibers in the brain of Rana pipiens. ...