4-aminosalicylic acid

Names

[ CAS No. ]:
65-49-6

[ Name ]:
4-aminosalicylic acid

[Synonym ]:
PAS
4-Asa
Bactylan
Pasalon-rakeet
Aminox
Tubersan
para-amino salicylic acid
Salvis
Paracipan
4-Amino-2-hydroxybenzoic acid
Sanipirol
Lepasen
PASA
Apas
Pasmicina
p-aminosalicylic acid
Benzoic acid, 4-amino-2-hydroxy-
Rezipas
4-amino-salicylic acid
EINECS 200-613-5
ZR CQ DVQ
Passodico
PASK
4-Aminosalicylic acid
MFCD00007789
A 1909
Aminosalicylic Acid
Aminacyl
Paser
PAS-C
Pasem
Mesalazine Impurity 5

Biological Activity

[Description]:

4-Aminosalicylic acid (ASA) is an orally active antibiotic and has the potential to treat tuberculosis[1].

[Related Catalog]:

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Vânia André, et al. Crystal Forms of the Antibiotic 4-Aminosalicylic Acid: Solvates and Molecular Salts with Dioxane, Morpholine, and Piperazine. Cryst. Growth Des. 2009, 9, 12, 5108-5116.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
380.8±32.0 °C at 760 mmHg

[ Melting Point ]:
135-145 °C(lit.)

[ Molecular Formula ]:
C₇H₇NO₃

[ Molecular Weight ]:
153.135

[ Flash Point ]:
184.1±25.1 °C

[ Exact Mass ]:
153.042587

[ PSA ]:
83.55000

[ LogP ]:
1.14

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.691

[ Water Solubility ]:
2 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VO1225000

CHEMICAL NAME :: Salicylic acid, 4-amino-

CAS REGISTRY NUMBER :: 65-49-6

BEILSTEIN REFERENCE NO. :: 0473071

LAST UPDATED :: 199701

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C7-H7-N-O3

MOLECULAR WEIGHT :: 153.15

WISWESSER LINE NOTATION :: ZR CQ DVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3898 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3650 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - mouse Mammary gland

DOSE/DURATION :: 2 mmol/L/24H (Continuous)

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 5,141,1980 *** REVIEWS *** TOXICOLOGY REVIEW AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 38,409,1965

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39-S45-S53

[ RIDADR ]:
UN 1789 8/PG 3

[ WGK Germany ]:
2

[ RTECS ]:
VO1225000

[ HS Code ]:
29225000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 29225000

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