m-PEG7-thiol

Names

[ Name ]:
m-PEG7-thiol

[Synonym ]:
O-(2-Mercaptoethyl)-O inverted exclamation marka-methyl-hexa(ethylene glycol)
AmbotzPEG1167
mPEG thiol
2,5,8,11,14,17,20-HEPTAOXADOCOSANE-22-THIOL
O-(2-Mercaptoethyl)-O'-methyl-hexa(ethylene glycol)

Biological Activity

[Description]:

m-PEG7-thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.065

[ Molecular Formula ]:
C₁₅H₃₂O₇S

[ Molecular Weight ]:
356.47500

[ Exact Mass ]:
356.18700

[ PSA ]:
103.41000

[ LogP ]:
0.66220

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Enhanced thermal stability of silica-coated gold nanorods for photoacoustic imaging and image-guided therapy.

Opt. Express 18 , 8867-78, (2010)

Photothermal stability and, therefore, consistency of both optical absorption and photoacoustic response of the plasmonic nanoabsorbers is critical for successful photoacoustic image-guided phototherm...