SPCK

Names

[ Name ]:
SPCK

[Synonym ]:
methyl 4-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(3S)-1-chloro-4-methyl-2-oxopentan-3-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoate
MeOSuc-Ala-Ala-Pro-Val-CMK
Meosuc-aapv-cmk
Methoxy-suc-ala-ala-pro-val-chloromethyl ketone
Msaapvck
methoxysuccinyl-alanyl-alanyl-prolyl-valine chloromethyl ketone
Elastase Inhibitor,SPCK
MeOSuc-Ala-Ala-Pro-Val-chloromethylketone

Biological Activity

[Description]:

MeOSuc-AAPV-CMK (Elastase Inhibitor III) is an elastase inhibitor. MeOSuc-AAPV-CMK also inhibits cathepsin G and proteinase 3.MeOSuc-AAPV-CMK blocks the cleavage of adiponectin by leukocyte elastase[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Metabolic Enzyme/Protease >> Elastase

Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin

[References]

[1]. Waki H, et al. Generation of globular fragment of adiponectin by leukocyte elastase secreted by monocytic cell line THP-1. Endocrinology. 2005 Feb;146(2):790-6.

[2]. Middelhoven PJ, Vet al. Different proteolytic mechanisms involved in Fc gamma RIIIb shedding from human neutrophils. Clin Exp Immunol. 2001 Jul;125(1):169-75.

Chemical & Physical Properties

[ Density]:
1.234g/cm3

[ Boiling Point ]:
809.4ºC at 760 mmHg

[ Melting Point ]:
159-161ºC

[ Molecular Formula ]:
C₂₂H₃₅ClN₄O₇

[ Molecular Weight ]:
502.98900

[ Flash Point ]:
443.3ºC

[ Exact Mass ]:
502.21900

[ PSA ]:
150.98000

[ LogP ]:
0.99930

[ Index of Refraction ]:
1.513

[ Storage condition ]:
20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Comparison of the effects of methoxysuccinyl-Ala-Ala-Pro-Val-chloromethyl ketone-inhibited neutrophil elastase with the effects of its naturally occurring mutationally inactivated homologue (HBP) on fibroblasts and monocytes in vitro.

APMIS 100(12) , 1073-80, (1992)

The mature neutrophils in the circulation contain, besides the different proteases known for a long time, a recently discovered proteolytically inactive elastase homologue (HBP/CAP37/azurocidin). This...

Polymorphonuclear cells isolated from human peripheral blood cleave lipoprotein(a) and apolipoprotein(a) at multiple interkringle sites via the enzyme elastase. Generation of mini-Lp(a) particles and apo(a) fragments.

J. Biol. Chem. 272(17) , 11079-87, (1997)

Incubation of polymorphonuclear cells (PMN), isolated from human peripheral blood, with either lipoprotein(a) (Lp(a)) or free apolipoprotein(a) (apo(a)), derived from the parent Lp(a), caused in both ...

In vitro proteolysis of human plasma low density lipoproteins by an elastase released from human blood polymorphonuclear cells.

J. Biol. Chem. 261(5) , 2057-63, (1986)

In vitro incubation of human plasma low density lipoproteins (LDL) with human blood polymorphonuclear cells (PMN) for 1 h at 37 degrees C resulted in an increased (2-4-fold) release into the medium of...