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1-Methoxyphaseollidin

Names

[ CAS No. ]:
65428-13-9

[ Name ]:
1-Methoxyphaseollidin

[Synonym ]:
EINECS 2017-001-1

Biological Activity

[Description]:

1-Methoxyphaseollidin, a flavonoid compound, is a lysoPAF acetyltransferase inhibitor, with an IC50 of 48 μM. 1-Methoxyphaseollidin exhibits anti-H.pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains[1][2][3].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

Human Endogenous Metabolite


[References]

[1]. Fukai T, et, al. Anti-Helicobacter pylori flavonoids from licorice extract. Life Sci. 2002 Aug 9;71(12):1449-63.

[2]. Nagumo S, et, al. Inhibition of lysoPAF acetyltransferase activity by components of licorice root. Biol Pharm Bull. 1999 Oct;22(10):1144-6.

[3]. Sinha SK, et, al. Potential Leads from Liquorice Against SARS-CoV-2 Main Protease using Molecular Docking Simulation Studies. Comb Chem High Throughput Screen. 2021;24(4):591-597.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
521.7±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H22O5

[ Molecular Weight ]:
354.39638

[ Flash Point ]:
269.3±30.1 °C

[ Exact Mass ]:
354.146729

[ LogP ]:
4.32

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.621

[ Storage condition ]:
2-8℃

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds