2-Phospho-L-ascorbic acid trisodium salt

Names

[ Name ]:
2-Phospho-L-ascorbic acid trisodium salt

[Synonym ]:
Trisodium (5R)-5-[(1S)-1,2-dihydroxyethyl]-4-oxido-2-oxo-2,5-dihydro-3-furanyl phosphate
2-Phospho-L-ascorbic acid trisodium salt
MFCD04038081

Biological Activity

[Description]:

2-Phospho-L-ascorbic acid trisodium salt acts as an antioxidant and a stimulator of hepatocyte growth factor (HGF) production.

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Met/HGFR

[In Vitro]

2-Phospho-L-ascorbic acid (Asc 2-P) acts as an antioxidant and a stimulator of hepatocyte growth factor (HGF) production. 2-Phospho-L-ascorbic acid is a stable derivative of L-ascorbic acid (AA) and possesses similar biological properties as AA. AA and Asc-2P regulate a number of biological processes[1]. When 2-Phospho-L-ascorbic acid is added together with DHT, DHT-induced DKK-1 mRNA expression in DPCs is significantly attenuated. It is also found that DKK-1 promoter activity is increased by DHT treatmen. When 2-Phospho-L-ascorbic acid is added together with DHT, DHT-induced activation of luciferase activity is significantly repressed[2].

[References]

[1]. Bae SH, et al. L-ascorbic acid 2-phosphate and fibroblast growth factor-2 treatment maintains differentiation potential in bone marrow-derived mesenchymal stem cells through expression of hepatocyte growth factor. Growth Factors. 2015 Apr;33(2):71-8.

[2]. Kwack MH, et al. L-ascorbic acid 2-phosphate represses the dihydrotestosterone-induced dickkopf-1 expression in human balding dermal papilla cells. Exp Dermatol. 2010 Dec;19(12):1110-2.

[Related Small Molecules]

Capmatinib (INCB28060) | Foretinib (GSK1363089) | PHA-665752 | BMS-777607 | Dihexa | Savolitinib | Tivantinib (ARQ 197) | tepotinib | LY2801653 | SGX-523 | DCC-2618 | SU11274 | Ensartinib | CEP-40783 | JNJ-38877605

Chemical & Physical Properties

[ Melting Point ]:
84 °C

[ Molecular Formula ]:
C₆H₆Na₃O₉P

[ Molecular Weight ]:
322.049

[ Exact Mass ]:
321.944244

[ PSA ]:
172.05000

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2932209090

Customs

[ HS Code ]: 2932209090

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

High-sensitive electrochemical detection of point mutation based on polymerization-induced enzymatic amplification.

Biosens. Bioelectron. 26 , 3187-3191, (2011)

Here a highly sensitive electrochemical method is described for the detection of point mutation in DNA. Polymerization extension reaction is applied to specifically initiate enzymatic electrochemical ...

Design of experiments approach to engineer cell-secreted matrices for directing osteogenic differentiation.

Ann. Biomed. Eng. 39 , 1174-1185, (2011)

The presentation of extracellular matrix (ECM) proteins provides an opportunity to instruct the phenotype and behavior of responsive cells. Decellularized cell-secreted matrix coatings (DM) represent ...

Modulating and modeling aggregation of cell-seeded microcarriers in stirred culture system for macrotissue engineering.

J. Biotechnol. 150 , 438-446, (2010)

A recently developed protocol, "microtissue assembly" holds great promise to address the issue of limited mass transfer within engineered large tissue replacements (macrotissues), wherein small "build...