Wnt pathway inhibitor 3

Names

[ Name ]:
Wnt pathway inhibitor 3

[Synonym ]:
8-[4-(Allyloxy)-3-bromo-5-methoxyphenyl]-6-amino-8H-[1,3]dioxolo[4,5-g]chromene-7-carbonitrile
8H-1,3-Dioxolo[4,5-g][1]benzopyran-7-carbonitrile, 6-amino-8-[3-bromo-5-methoxy-4-(2-propen-1-yloxy)phenyl]-

Biological Activity

[Description]:

Wnt pathway inhibitor 3 is a potent wnt inhibitor with an IC50 value of 45 nM. Wnt pathway inhibitor 3 shows antiproliferative activity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Stem Cell/Wnt >> Wnt

[Target]

IC50: 45 nM (wnt)[1]

[In Vitro]

Wnt pathway inhibitor 3 (compound 41) (0-100 000nM; 72 h) 显示抗增殖活性，对 HS68、Dld1、HCT116、SW480 细胞的 IC50 值分别为 641、470、551、618 nM[1]。

[References]

[1]. Michael Boutros, et al. Chromene derivatives and their analoga as wnt pathway antagonists. US20130296344A1.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
587.0±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₁₇BrN₂O₅

[ Molecular Weight ]:
457.27

[ Flash Point ]:
308.8±30.1 °C

[ Exact Mass ]:
456.032074

[ LogP ]:
4.14

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.679