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Melatonin D5

Names

[ CAS No. ]:
66521-38-8

[ Name ]:
Melatonin D5

[Synonym ]:
N-[1,1,2,2-tetradeuterio-2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide

Biological Activity

[Description]:

Melatonin D5 is deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Antioxidative and anti-inflammatory properties[1][2][3]. Melatonin is a selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation[4].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Neuronal Signaling >> Melatonin Receptor
Signaling Pathways >> Autophagy >> Autophagy
Signaling Pathways >> GPCR/G Protein >> Melatonin Receptor
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Autophagy >> Mitophagy
Research Areas >> Neurological Disease

[References]

[1]. Kilic U, et al. Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice. Redox Biol. 2017 Apr 5;12:657-665

[2]. Hu C, et al. Neuroprotective effect of melatonin on soluble Aβ1-42-induced cortical neurodegeneration via Reelin-Dab1 signaling pathway. Neurol Res. 2017 Apr 7:1-1

[3]. Rahim I, et al. Melatonin administration to wild-type mice and non-treated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis. J Pineal Res. 2017 Mar 31

[4]. Bu LJ, et al. Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation. World J Gastroenterol. 2017 Feb 14;23(6):986-998.

Chemical & Physical Properties

[ Density]:
1.196g/cm3

[ Boiling Point ]:
512.831ºC at 760 mmHg

[ Melting Point ]:
117-118ºC

[ Molecular Formula ]:
C13H12D4N2O2

[ Molecular Weight ]:
236.30300

[ Flash Point ]:
263.951ºC

[ Exact Mass ]:
236.14600

[ PSA ]:
54.12000

[ LogP ]:
2.24600

[ Index of Refraction ]:
1.6

[ Storage condition ]:
-20C

Related Compounds