4-Hydroxyretinoic acid
Names
[ CAS No. ]:
66592-72-1
[ Name ]:
4-Hydroxyretinoic acid
[Synonym ]:
rac all-trans 4-Hydroxy Retinoic Acid
Biological Activity
[Description]:
4-Hydroxyretinoic acid (4-HRA) is a naturally occurring retinoid derivative with diverse biological effects. 4-Hydroxyretinoic acid is formed from retinol catalyzed by cytochrome P-450 isozyme(s), and is mainly metabolized by the liver in the body. 4-Hydroxyretinoic acid also serves as the substrate for human liver microsomal UDP-glucuronosyltransferase(s) and recombinant UGT2B7. 4-Hydroxyretinoic acid regulates gene expression and cell differentiation via binding to nuclear receptor RAR (Retinoic Acid Receptor), and activates RARs and RXR-alpha, to induce cancer cell apoptosis. In addition, 4-Hydroxyretinoic acid is also involved in various physiological processes such as immune regulation, neuroprotection, and anti-oxidation[1][2].
[Related Catalog]:
[Target]
UDP-glucuronosyltransferase, cytochrome P-450 isozyme[1]; RAR, RXR-alpha[2]
[References]
Chemical & Physical Properties
[ Density]:
1.075g/cm3
[ Boiling Point ]:
506.5ºC at 760 mmHg
[ Molecular Formula ]:
C20H28O3
[ Molecular Weight ]:
316.43
[ Flash Point ]:
274.2ºC
[ Exact Mass ]:
316.20400
[ PSA ]:
57.53000
[ LogP ]:
4.57340
[ Index of Refraction ]:
1.574