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Ethyl caffeate

Names

[ CAS No. ]:
66648-50-8

[ Name ]:
Ethyl caffeate

[Synonym ]:
Ethyl caffeate
MFCD00045754
caffeic acid ethyl ester
2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-, ethyl ester
ethyl caffeoate
Ethyl 3-(3,4-dihydroxyphenyl)acrylate
E-Caffeic acid ethyl ester

Biological Activity

[Description]:

Ethyl trans-caffeate is the trans form of Ethyl Caffeate (HY-N6966). Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and prostaglandin E2 (PGE2) in vitro or in mouse skin[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[References]

[1]. Chiang YM, et al. Ethyl caffeate suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin. Br J Pharmacol. 2005 Oct;146(3):352-63.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
377.0±32.0 °C at 760 mmHg

[ Molecular Formula ]:
C11H12O4

[ Molecular Weight ]:
208.211

[ Flash Point ]:
148.4±18.6 °C

[ Exact Mass ]:
208.073563

[ PSA ]:
66.76000

[ LogP ]:
1.72

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.612

[ Storage condition ]:
2-8℃

Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

Related Compounds