4',5-Dihydroxyflavone

Names

[ Name ]:
4',5-Dihydroxyflavone

[Synonym ]:
4H-1-Benzopyran-4-one, 5-hydroxy-2-(4-hydroxyphenyl)-
4',5-Dihydroxyflavone
5-Hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
4',5-dihydroxy flavone
5,4'-Dihydroxyflavone

Biological Activity

[Description]:

4',5-Dihydroxyflavone is a soybean LOX-1 and yeast α-Glucosidase inhibitor, with an Ki of 102.6 μM for soybean LOX-1 and an IC50 of 66 μM for yeast α-glucosidase.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase

Research Areas >> Others

[Target]

Ki: 102.6 μM (LOX-1)[1]. IC50: 66 μM (α-glucosidase)[2].

[References]

[1]. Ribeiro D, et al. Inhibition of LOX by flavonoids: a structure-activity relationship study. Eur J Med Chem. 2014 Jan 24;72:137-45.

[2]. Proença C, et al. α-Glucosidase inhibition by flavonoids: an in vitro and in silico structure-activity relationship study. J Enzyme Inhib Med Chem. 2017 Dec;32(1):1216-1228.

[Related Small Molecules]

U73122 | Zileuton | ML355 | Nordihydroguaiaretic acid | Indirubin-3'-monoxime | Caffeic acid | marmesin | Malotilate | Enazadrem | LY 178002 | RWJ 63556 | S-2474 | 5-Lipoxygenase-In-1 | A-69412 | AZD 4407

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
486.0±45.0 °C at 760 mmHg

[ Melting Point ]:
239-240ºC

[ Molecular Formula ]:
C₁₅H₁₀O₄

[ Molecular Weight ]:
254.238

[ Flash Point ]:
190.0±22.2 °C

[ Exact Mass ]:
254.057907

[ PSA ]:
70.67000

[ LogP ]:
2.32

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.699

[ Storage condition ]:
2-8℃

Safety Information

[ HS Code ]:
2914501900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914501900

[ Summary ]:
2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%