6-Monohydroxyflavone

Names

[ Name ]:
6-Monohydroxyflavone

[Synonym ]:
EINECS 229-704-8
4H-1-Benzopyran-4-one, 6-hydroxy-2-phenyl-
6-Monohydroxyflavone
MFCD00017329
6-hydroxy-2-phenylchromen-4-one
6-Hydroxy-2-phenyl-4H-chromen-4-one

Biological Activity

[Description]:

6-Hydroxyflavone is a naturally occurring flavone, with anti-inflammatory activity. 6-Hydroxyflavone exhibits inhibitory effect towards bovine hemoglobin (BHb) glycation. 6-Hydroxyflavone can activate AKT, ERK 1/2, and JNK signaling pathways to effectively promote osteoblastic differentiation. 6-Hydroxyflavone inhibits the LPS-induced NO production[1] [2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Das S, et al. Characterization of non-covalent binding of 6-hydroxyflavone and 5,7-dihydroxyflavone with bovine hemoglobin: Multi-spectroscopic and molecular docking analyses. J Photochem Photobiol B. 2018 Jan;178:40-52.

[2]. Lai CH, et al. Effects of 6-Hydroxyflavone on Osteoblast Differentiation in MC3T3-E1 Cells. Evid Based Complement Alternat Med. 2014;2014:924560.

[3]. Wang X, et al. 6-Hydroxyflavone and derivatives exhibit potent anti-inflammatory activity among mono-, di- and polyhydroxylated flavones in kidney mesangial cells. PLoS One. 2015 Mar 19;10(3):e0116409.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
450.1±45.0 °C at 760 mmHg

[ Melting Point ]:
234-236 °C(lit.)

[ Molecular Formula ]:
C₁₅H₁₀O₃

[ Molecular Weight ]:
238.238

[ Flash Point ]:
176.3±22.2 °C

[ Exact Mass ]:
238.062988

[ PSA ]:
50.44000

[ LogP ]:
3.72

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.666

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ WGK Germany ]:
3

[ HS Code ]:
2914400090

Synthetic Route

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Customs

[ HS Code ]: 2914400090

[ Summary ]:
2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%