Destruxin A

Names

[ Name ]:
Destruxin A

[Synonym ]:
Destruxin A from Metarrhizium anisopliae

Biological Activity

[Description]:

Destruxin A (DA) is a cyclo-peptidic mycotoxin from the entomopathogenic fungus Metarhizium anisopliae, with insecticidal, anti-viral and antiproliferative activities[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Others >> Others

[References]

[1]. Gong L, et al. Gene expression profile of Bombyx mori hemocyte under the stress of destruxin A. PLoS One. 2014 May 6;9(5):e96170.

[2]. Pal S, et al. Fungal peptide Destruxin A plays a specific role in suppressing the innate immune response in Drosophila melanogaster. J Biol Chem. 2007 Mar 23;282(12):8969-77.

[3]. Odier F, et al. In vitro effect of fungal cyclodepsipeptides on leukemic cells: study of destruxins A, B and E. Biol Cell. 1992;74(3):267-71.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₄₇N₅O₇

[ Molecular Weight ]:
577.71300

[ Exact Mass ]:
577.34800

[ PSA ]:
152.41000

[ LogP ]:
1.21150

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H315-H319-H332-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Risk Phrases ]:
20/21/22-36/37/38-48

[ Safety Phrases ]:
26-36-45

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
HH1500000

Articles

Concurrence of losing a chromosome and the ability to produce destruxins in a mutant of Metarhizium anisopliae.

FEMS Microbiol. Lett. 226(2) , 373-8, (2003)

In a previous study, a spontaneous subtilisin pr1A and pr1B gene-deficient mutant of the entomopathogenic fungus Metarhizium anisopliae strain V275 has been identified [Wang, C.-S. et al. (2002) FEMS ...

Synthesis and biological evaluation of destruxin A and related analogs.

J. Pept. Res. 58(1) , 1-11, (2001)

This report describes the development of an efficient solid-phase synthesis protocol and adaptation of reported solution phase procedures for the synthesis of the cyclic depsihexapeptide destruxin A a...

Non-cyclic AMP-dependent, positive inotropic cyclodepsipeptides with negative chronotropy.

J. Pharmacol. Exp. Ther. 290(3) , 1006-12, (1999)

The effects of natural cyclodepsipeptides (CDPs) on isolated rat cardiac tissue preparations were examined in vitro. Destruxin A, destruxin B (DB), roseotoxin B (RB), and roseocardin (RC), a novel CDP...