Diethylenetriaminepentaacetic acid

Names

[ CAS No. ]:
67-43-6

[ Name ]:
Diethylenetriaminepentaacetic acid

[Synonym ]:
9-Propylamino-phenanthren
DTPA
N,N-Bis{2-[bis(carboxymethyl)amino]ethyl}glycine
Pentacarboxymethyl Diethylenetriamine
9-Phenanthrenamine,N-propyl
N,N-bis[2-[bis(carboxymethyl)-amino]ethyl]glycine
N,N,N',N'',N''-diethylenetriaminepentaacetic acid
Glycine, N,N-bis(2-(bis(carboxymethyl)amino)ethyl)-
Diethylenetriaminepentaacetic acid
diethylenetrinitrilopentaacetic acid
diethylenetriamine-N,N,N',N'',N''-pentaacetic acid
Pentetic acid
[9]phenanthryl-propyl-amine
Clewat DA
2,2',2'',2''',2''''-(1,2-Ethanediylnitrilo)pentaacetic acid
diethylenetriamine pentaacetic acid
[9]Phenanthryl-propyl-amin
EINECS 200-652-8
N-n-propyl-9-phenanthrenamine
MFCD00004289

Biological Activity

[Description]:

Pentetic acid is a compound used to construct magnetic adsorbent, which can simultaneously remove heavy metal and dye from complex wastewater[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Huang Y, et al. Enhanced selective adsorption of lead(II) from complex wastewater by DTPA functionalized chitosan-coated magnetic silica nanoparticles based on anion-synergism. J Hazard Mater. 2022;422:126856.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
721.1±60.0 °C at 760 mmHg

[ Melting Point ]:
219-220 °C(lit.)

[ Molecular Formula ]:
C₁₄H₂₃N₃O₁₀

[ Molecular Weight ]:
393.346

[ Flash Point ]:
389.9±32.9 °C

[ Exact Mass ]:
393.138336

[ PSA ]:
196.22000

[ LogP ]:
0.05

[ Vapour Pressure ]:
0.0±5.0 mmHg at 25°C

[ Index of Refraction ]:
1.590

[ Storage condition ]:
-20°C

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
5 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MB8205000

CHEMICAL NAME :: Glycine, N,N-bis(2-(bis(carboxymethyl)amino)ethyl)-

CAS REGISTRY NUMBER :: 67-43-6

BEILSTEIN REFERENCE NO. :: 1810219

LAST UPDATED :: 199710

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C14-H23-N3-O10

MOLECULAR WEIGHT :: 393.40

WISWESSER LINE NOTATION :: QV1N1VQ2N1VQ2N1VQ1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 587 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - aggression Lungs, Thorax, or Respiration - chronic pulmonary edema

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 32,37,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 543 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 57,212,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M3891 No. of Facilities: 735 (estimated) No. of Industries: 6 No. of Occupations: 9 No. of Employees: 2599 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M3891 No. of Facilities: 1070 (estimated) No. of Industries: 9 No. of Occupations: 14 No. of Employees: 10918 (estimated) No. of Female Employees: 7008 (estimated)

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319-H332-H361d

[ Precautionary Statements ]:
P281-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;N:Dangerousfortheenvironment;

[ Risk Phrases ]:
R36/37/38;R51/53

[ Safety Phrases ]:
S26-S36-S61-S37/39

[ RIDADR ]:
UN 3077 9/PG 3

[ WGK Germany ]:
2

[ RTECS ]:
MB8205000

[ Hazard Class ]:
9.0

[ HS Code ]:
29224995

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2916190090

[ Summary ]:
2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

Articles

Investigation of a Degradant in a Biologics Formulation Buffer Containing L-Histidine.

Pharm. Res. 32 , 2625-35, (2015)

An unknown UV 280 nm absorbing peak was observed by SEC for protein stability samples formulated in L-histidine during a stress stability study. Understanding the source would enhance the confidence i...

Effect of co-ligands on chemical and biological properties of (99m)Tc(III) complexes [(99m)Tc(L)(CDO)(CDOH)2BMe] (L=Cl, F, SCN and N3; CDOH2=cyclohexanedione dioxime).

Nucl. Med. Biol. 41(10) , 813-24, (2014)

(99m)Tc-Teboroxime ([(99m)TcCl(CDO)(CDOH)2BMe]) is a member of the BATO (boronic acid adducts of technetium dioximes) class of (99m)Tc(III) complexes. This study sought to explore the impact of co-lig...

Dicarbonyl Induced Structural Perturbations Make Histone H1 Highly Immunogenic and Generate an Auto-Immune Response in Cancer.

PLoS ONE 10 , e0136197, (2015)

Increased oxidative stress under hyperglycemic conditions, through the interaction of AGEs with RAGE receptors and via activation of interleukin mediated transcription signalling, has been reported in...